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KMID : 0366220060410010046
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Korean Journal of Hematology
2006 Volume.41 No. 1 p.46 ~ p.50
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A Case of Acute Lymphoblastic Leukemia with Maturation
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Kim Jeong-Hun
Lee Woo-In
Park Su-Yon
Yoon Hwi-Joong
Kang So-Young
Suh Jin-Tae
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Abstract
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Acute lymphoblastic leukemia with maturation (ALLm) has different disease characteristics that does typical ALL. ALLm is characterized by an increased number of mature appearing leukemic cells (>20% of ANCs in the BM) having differentiation beyond the prolymphocyte stage according to light microscopic (LM) examination. It also has a worse prognosis than typical ALL. We have recently experienced a case of ALLm and we report on this case along with a literature review. A 36 year old patient showed lymphoblasts and mature appearing leukemic cells that were counted up to 15.8% and 23.0%, respectively, of the WBCs on bone marrow examination. Despite their mature appearance, these cells showed positivity for Tdt, CD10, CD19 and HLA-DR on the immunophenotypic study. Differentiating the mature-appearing leukemic cells from the hematogones or mature lymphocytes is difficult, and only through immunophenotypic examination is it possible to discriminate ALLm from typical ALL. We suggest performing a leukemic marker study that includes CD38 to effectively differentiate mature appearing leukemic cells from hematogones, especially for the follow up of leukemia with mature appearing cells.
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KEYWORD
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ALLm, Tdt, CD10, CD19, CD38 and HLA-DR
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